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si stat3 constructs  (Obio Technology Corp Ltd)

 
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    Obio Technology Corp Ltd si stat3 constructs
    Inhibition of STAT3/Drp1 signaling defends HG-induced oxidative stress and mitochondrial defects. (A) Western blotting of STAT3 protein levels in primary cultured astrocytes, and quantification data. n = 3. (B) Representative images of ROS content by flow cytometry analysis, and quantification data. n = 5. (C-E) MDA, GSH and SOD contents in primary cultured astrocytes. n = 5. (F) Representative images of the morphology of mitochondria by TEM in primary cultured astrocytes. Scale bar, 500 nm. (G) Mitochondrial aspect ratio, n = 3. (H) Mitochondrial cristae density, n = 3. (I) Western blotting of Mfn1, p -Drp1 and Drp1 protein levels in primary cultured astrocytes. (J) Representative images of JC-1 staining by flow cytometry analysis used to assess mitochondrial membrane potential. (K–N) OCR, ATP production, Basal respiration and Maximal respiration in primary cultured astrocytes. n = 5. si-NC (scrambled negative control <t>siRNA);</t> <t>si-STAT3</t> (si-STAT3 primer). (High glucose, 50 mmol/L treated 48 h). Data are shown as mean ± SEM or SD. Statistical significance was defined as ∗ P < 0.05, ∗∗ P < 0.01, and ∗∗∗ P < 0.001.
    Si Stat3 Constructs, supplied by Obio Technology Corp Ltd, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/si stat3 constructs/product/Obio Technology Corp Ltd
    Average 86 stars, based on 1 article reviews
    si stat3 constructs - by Bioz Stars, 2026-05
    86/100 stars

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    1) Product Images from "Astrocytic GSTM2-STAT3 interaction ameliorates the diabetes associated cognitive dysfunction via targeting mitochondrial defects and oxidative stress"

    Article Title: Astrocytic GSTM2-STAT3 interaction ameliorates the diabetes associated cognitive dysfunction via targeting mitochondrial defects and oxidative stress

    Journal: Redox Biology

    doi: 10.1016/j.redox.2026.104137

    Inhibition of STAT3/Drp1 signaling defends HG-induced oxidative stress and mitochondrial defects. (A) Western blotting of STAT3 protein levels in primary cultured astrocytes, and quantification data. n = 3. (B) Representative images of ROS content by flow cytometry analysis, and quantification data. n = 5. (C-E) MDA, GSH and SOD contents in primary cultured astrocytes. n = 5. (F) Representative images of the morphology of mitochondria by TEM in primary cultured astrocytes. Scale bar, 500 nm. (G) Mitochondrial aspect ratio, n = 3. (H) Mitochondrial cristae density, n = 3. (I) Western blotting of Mfn1, p -Drp1 and Drp1 protein levels in primary cultured astrocytes. (J) Representative images of JC-1 staining by flow cytometry analysis used to assess mitochondrial membrane potential. (K–N) OCR, ATP production, Basal respiration and Maximal respiration in primary cultured astrocytes. n = 5. si-NC (scrambled negative control siRNA); si-STAT3 (si-STAT3 primer). (High glucose, 50 mmol/L treated 48 h). Data are shown as mean ± SEM or SD. Statistical significance was defined as ∗ P < 0.05, ∗∗ P < 0.01, and ∗∗∗ P < 0.001.
    Figure Legend Snippet: Inhibition of STAT3/Drp1 signaling defends HG-induced oxidative stress and mitochondrial defects. (A) Western blotting of STAT3 protein levels in primary cultured astrocytes, and quantification data. n = 3. (B) Representative images of ROS content by flow cytometry analysis, and quantification data. n = 5. (C-E) MDA, GSH and SOD contents in primary cultured astrocytes. n = 5. (F) Representative images of the morphology of mitochondria by TEM in primary cultured astrocytes. Scale bar, 500 nm. (G) Mitochondrial aspect ratio, n = 3. (H) Mitochondrial cristae density, n = 3. (I) Western blotting of Mfn1, p -Drp1 and Drp1 protein levels in primary cultured astrocytes. (J) Representative images of JC-1 staining by flow cytometry analysis used to assess mitochondrial membrane potential. (K–N) OCR, ATP production, Basal respiration and Maximal respiration in primary cultured astrocytes. n = 5. si-NC (scrambled negative control siRNA); si-STAT3 (si-STAT3 primer). (High glucose, 50 mmol/L treated 48 h). Data are shown as mean ± SEM or SD. Statistical significance was defined as ∗ P < 0.05, ∗∗ P < 0.01, and ∗∗∗ P < 0.001.

    Techniques Used: Inhibition, Western Blot, Cell Culture, Flow Cytometry, Staining, Membrane, Negative Control



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    si stat3 constructs  (Obio Technology Corp Ltd)
    86
    Obio Technology Corp Ltd si stat3 constructs
    Inhibition of STAT3/Drp1 signaling defends HG-induced oxidative stress and mitochondrial defects. (A) Western blotting of STAT3 protein levels in primary cultured astrocytes, and quantification data. n = 3. (B) Representative images of ROS content by flow cytometry analysis, and quantification data. n = 5. (C-E) MDA, GSH and SOD contents in primary cultured astrocytes. n = 5. (F) Representative images of the morphology of mitochondria by TEM in primary cultured astrocytes. Scale bar, 500 nm. (G) Mitochondrial aspect ratio, n = 3. (H) Mitochondrial cristae density, n = 3. (I) Western blotting of Mfn1, p -Drp1 and Drp1 protein levels in primary cultured astrocytes. (J) Representative images of JC-1 staining by flow cytometry analysis used to assess mitochondrial membrane potential. (K–N) OCR, ATP production, Basal respiration and Maximal respiration in primary cultured astrocytes. n = 5. si-NC (scrambled negative control <t>siRNA);</t> <t>si-STAT3</t> (si-STAT3 primer). (High glucose, 50 mmol/L treated 48 h). Data are shown as mean ± SEM or SD. Statistical significance was defined as ∗ P < 0.05, ∗∗ P < 0.01, and ∗∗∗ P < 0.001.
    Si Stat3 Constructs, supplied by Obio Technology Corp Ltd, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/si stat3 constructs/product/Obio Technology Corp Ltd
    Average 86 stars, based on 1 article reviews
    si stat3 constructs - by Bioz Stars, 2026-05
    86/100 stars
    		  Buy from Supplier

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    Inhibition of STAT3/Drp1 signaling defends HG-induced oxidative stress and mitochondrial defects. (A) Western blotting of STAT3 protein levels in primary cultured astrocytes, and quantification data. n = 3. (B) Representative images of ROS content by flow cytometry analysis, and quantification data. n = 5. (C-E) MDA, GSH and SOD contents in primary cultured astrocytes. n = 5. (F) Representative images of the morphology of mitochondria by TEM in primary cultured astrocytes. Scale bar, 500 nm. (G) Mitochondrial aspect ratio, n = 3. (H) Mitochondrial cristae density, n = 3. (I) Western blotting of Mfn1, p -Drp1 and Drp1 protein levels in primary cultured astrocytes. (J) Representative images of JC-1 staining by flow cytometry analysis used to assess mitochondrial membrane potential. (K–N) OCR, ATP production, Basal respiration and Maximal respiration in primary cultured astrocytes. n = 5. si-NC (scrambled negative control siRNA); si-STAT3 (si-STAT3 primer). (High glucose, 50 mmol/L treated 48 h). Data are shown as mean ± SEM or SD. Statistical significance was defined as ∗ P < 0.05, ∗∗ P < 0.01, and ∗∗∗ P < 0.001.

    Journal: Redox Biology

    Article Title: Astrocytic GSTM2-STAT3 interaction ameliorates the diabetes associated cognitive dysfunction via targeting mitochondrial defects and oxidative stress

    doi: 10.1016/j.redox.2026.104137

    Figure Lengend Snippet: Inhibition of STAT3/Drp1 signaling defends HG-induced oxidative stress and mitochondrial defects. (A) Western blotting of STAT3 protein levels in primary cultured astrocytes, and quantification data. n = 3. (B) Representative images of ROS content by flow cytometry analysis, and quantification data. n = 5. (C-E) MDA, GSH and SOD contents in primary cultured astrocytes. n = 5. (F) Representative images of the morphology of mitochondria by TEM in primary cultured astrocytes. Scale bar, 500 nm. (G) Mitochondrial aspect ratio, n = 3. (H) Mitochondrial cristae density, n = 3. (I) Western blotting of Mfn1, p -Drp1 and Drp1 protein levels in primary cultured astrocytes. (J) Representative images of JC-1 staining by flow cytometry analysis used to assess mitochondrial membrane potential. (K–N) OCR, ATP production, Basal respiration and Maximal respiration in primary cultured astrocytes. n = 5. si-NC (scrambled negative control siRNA); si-STAT3 (si-STAT3 primer). (High glucose, 50 mmol/L treated 48 h). Data are shown as mean ± SEM or SD. Statistical significance was defined as ∗ P < 0.05, ∗∗ P < 0.01, and ∗∗∗ P < 0.001.

    Article Snippet: The OE-GSTM2 and si-STAT3 constructs utilized in this study were custom-designed and procured from OBio Technology Co. Ltd. (Shanghai, China).

    Techniques: Inhibition, Western Blot, Cell Culture, Flow Cytometry, Staining, Membrane, Negative Control